Relationship Between Toxicogenomic and Environment and Lung Cancer

Tobacco-smoke is associated with 75-90% of LC cases and ~50% occurs in developing countries (Parkin, et al. 2005; Parkin, et al. 1994). Several studies have demonstrated that organic and inorganic compounds are related with the development of cancer, including LC (Bradley and Golden 2006; De Palma, et al. 2008; Stavrides 2006). The association between cigarette smoking and various types of respiratory cancer has been demonstrated (U.S.EPA 2001) and many carcinogenic compounds present in cigarette smoke, such as polycyclic aromatic hydrocarbons (PAHs), have also been identified in airborne particles in different cities around the world (Adonis, et al. 1997; Gil, et al. 1995; Minoia, et al. 1997; Monarca, et al. 1998).